{"id":68,"date":"2019-08-28T12:47:39","date_gmt":"2019-08-28T12:47:39","guid":{"rendered":"http:\/\/www.cironpharma.com\/blog\/?p=68"},"modified":"2019-09-25T06:59:16","modified_gmt":"2019-09-25T06:59:16","slug":"the-world-of-pharmaceutical-preservatives","status":"publish","type":"post","link":"https:\/\/www.cironpharma.com\/blog\/the-world-of-pharmaceutical-preservatives\/","title":{"rendered":"The World of Pharmaceutical Preservatives"},"content":{"rendered":"\n<p>Preservatives are substances that are generally\nadded to foods and pharmaceutical products. These preservatives are added in\nyour antibiotics, antiviral and antifungal pharmaceutical medicines to prevent\nany kind of physical, chemical and biological changes in them, to prolong their\nshelf life, to enhance activity and efficacy and to stabilize the\npharmaceutical product. <\/p>\n\n\n\n<p><strong>How\nshould an ideal pharmaceutical preservative look like?<\/strong><\/p>\n\n\n\n<ul><li><strong>Stable<\/strong><\/li><li><strong>Odorless<\/strong><\/li><li><strong>Cost-effective<\/strong><\/li><li><strong>Compatible\nwith drug components <\/strong><\/li><li><strong>Effective\n<\/strong><\/li><li><strong>Non-toxic\nand non-reactive preservative <\/strong><\/li><li><strong>Highly\nsoluble <\/strong><\/li><\/ul>\n\n\n\n<p>In addition to the above pointers, there are few other things that <strong><a href=\"http:\/\/www.cironpharma.com\/blog\/behind-pharma-doors-how-formulations-are-made\/\">Formulation Companies in India<\/a><\/strong> should keep in mind before choosing a preservative for their pharmaceutical drug: <\/p>\n\n\n\n<ul><li>The pharmaceutical preservative\nshould not affect patient safety or tolerance of the product.<\/li><li>Maintain activity throughout the\nshelf life of your pharmaceutical product. <\/li><li>Not compromise the quality or\nperformance of the pharma drug<\/li><\/ul>\n\n\n\n<p>Let\u2019s have a look at the different types of preservatives used by <strong><a href=\"http:\/\/www.cironpharma.com\/profile.asp\">Manufacturer of Formulated Products<\/a><\/strong> in pharmaceutical medicines:\u00a0 <\/p>\n\n\n\n<p><strong>Antimicrobial\nPreservatives: <\/strong>These agents in your pharma products\nact against the microorganisms in your body and thereby inhibiting their\ndangerous and harmful growth.&nbsp; <\/p>\n\n\n\n<p>However, there are some factors that to be\nconsidered before selecting your antimicrobial preservatives\u2026 let\u2019s have a look\nat them: <\/p>\n\n\n\n<ul><li>Its effect on active ingredient and excipients<\/li><li>The preservative dosage depending on the type of pharmaceutical drug that you are manufacturing. Example: Antifungal medicines by <strong><a href=\"http:\/\/www.cironpharma.com\/blog\/career-watch-a-look-at-how-indian-pharmaceutical-organizations-are-lapping-up-young-aspirants\/\">Pharmaceutical Product Manufacturing Companies<\/a> <\/strong>require more amount of antimicrobial preservatives than antibiotics. <\/li><\/ul>\n\n\n\n<p>Sterile preparations such as eye drop and nose\ndrops which contain considerable content of water are at risk of microbial\nspoilage and need high amount of antimicrobial preservatives in their\npharmaceutical formulation preparation.<\/p>\n\n\n\n<p><strong>Antioxidant\nPreservatives<\/strong>: One of the most commonly used preservatives.\nAntioxidants are self reducing agents that oxidize themselves and prevent\noxidization of the vital components of your pharmaceutical formulation that are\nsensitive to oxygen. (Both Vitamin C &amp; E are extremely sensitive to oxygen\nand light) Different types of antioxidant preservatives: BHA (Butylated\nhydroxyanisole) BHT (Butylated hydroxytoluene) and Propyl gate.<\/p>\n\n\n\n<p><strong>Chelating\nPreservatives: <\/strong>A term derived from the Greek word\n\u2018chele\u2019 which means crocodile\u2019s claw. Chelating preservatives are mainly used\nto prolong the shelf life of antibiotic drugs. <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Preservatives are substances that are generally added to foods and pharmaceutical products. These preservatives are added in your antibiotics, antiviral and antifungal pharmaceutical medicines to prevent any kind of physical, chemical and biological changes in them, to prolong their shelf life, to enhance activity and efficacy and to stabilize the pharmaceutical product. How should an<\/p>\n","protected":false},"author":1,"featured_media":69,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[5],"_links":{"self":[{"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/posts\/68"}],"collection":[{"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/comments?post=68"}],"version-history":[{"count":2,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/posts\/68\/revisions"}],"predecessor-version":[{"id":71,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/posts\/68\/revisions\/71"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/media\/69"}],"wp:attachment":[{"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/media?parent=68"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/categories?post=68"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cironpharma.com\/blog\/wp-json\/wp\/v2\/tags?post=68"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}